MicroRNA-155: Regulation of Immune Cells in Sepsis

Table 1

Targeted genes of miR-155 that have been experimentally confirmed.

No.	Target gene	Function
1	SOCS1	Regulator of cytokine signal transduction
2	CEBPB	Related to the regulation of proinflammatory cytokines during macrophage activation and the acute phase response
3	TP53INP1	Proapoptotic stress-induced p53 target gene
4	INPP5D/SHIP1	Negative regulator of cell proliferation and survival
5	FOXO3	Tumor suppressor
6	BACH1	Transcription regulator protein
7	AGTR1	Mediates the major cardiovascular effects of angiotensin II
8	TAB2	Activator of MAP3K7/TAK1
9	SMAD2	Mediates the signal of the transforming growth factor- (TGF-) β
10	SMAD5	Modulates signals of bone morphogenetic proteins (BMPs)
11	JARID2	Organ development
12	SPI1/PU.1	Myeloid and B-lymphoid cell development
13	ETS1	Related to the differentiation and development of immune cells
14	E2F2	Regulation of cell cycle and tumor suppressor protein
15	SIRT1	Cellular regulation related protein deacetylating enzyme