Topical Administration of 15-Deoxy-<i>Δ</i><sup>12,14</sup>-Prostaglandin J<sub>2</sub> Using a Nonionic Cream: Effect on UVB-Induced Skin Oxidative, Inflammatory, and Histopathological Modifications in Mice

<div>Topical formulation containing 15d-PGJ<sub>2</sub> (TFcPGJ<sub>2</sub>) inhibits UVB irradiation-induced collagen fiber damage. Collagen fiber degradation was evaluated with Masson’s trichrome staining in skin samples collected 12 h after the irradiation. Collagen fiber intensity and bundles shown in blue were examined by the ImageJ program (10x magnification). NC: negative control; PC: positive control; uTF: unloaded topical formulation. 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Mediators of Inflammation

fig8

Figure 8

Figure 8: Topical Administration of 15-Deoxy-<i>Δ</i><sup>12,14</sup>-Prostaglandin J<sub>2</sub> Using a Nonionic Cream: Effect on UVB-Induced Skin Oxidative, Inflammatory, and Histopathological Modifications in Mice 

Figure 8 | Topical Administration of 15-Deoxy-Δ12,14-Prostaglandin J2 Using a Nonionic Cream: Effect on UVB-Induced Skin Oxidative, Inflammatory, and Histopathological Modifications in Mice 