Role of Epigenetics in the Pathogenesis, Treatment, Prediction, and Cellular Transformation of Asthma

Table 2

Some histone-modified genes, epigenetic modifications with clinical outcome.

Genes	Epigenetic modifications	Clinical outcome	References
Glucocorticoid receptor (GRa)	HDAC2 downregulation	Severe asthma	[87]
Notch-1	Hyperacetylation of H3K9, H3K14, H3K18, H3K27, and H3K16 and trimethylation of H3K4 and H3K79	Asthma	[88]
LAT	Hypoacetylation	Asthma	[89]
SOX2	HDAC1 upregulation	Asthma	[90]
IFN-γ, IL-17A, IL-17F, IL-4, Foxp3, RORγt	H3K4 trimethylation (H3K4me3)	Asthma/allergic diseases	[91]
IL-13, Foxp3	Acetylation	Asthma	[92]
ORMDL3	Hyperacetylation	Asthma	[93]
ΔNp63, STAT6, EGFR	H3K18 acetylation	Asthma	[94]
CXCL8	H3K18 acetylation	Asthma	[95]
CCR4, CCL5	H3K4 dimethylation	Asthma	[96]