Inverse Agonist of Retinoid-Related Orphan Receptor-Alpha Prevents Apoptosis and Degeneration in Nucleus Pulposus Cells via Upregulation of YAP

<div>SR3335 treatment decreased the nucleus pulposus ECM catabolism upon TNF-<i>α</i> treatment. The NP cells were pretreated with 1 <i>μ</i>M of SR3335 2 h before 10 ng/ml TNF-<i>α</i> treatment. (a) The mRNA level of COL2A1, ACAN, MMP13, and ADAMTS4 was assayed by real-time PCR. 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(b) The protein level of COL2A1, MMP13, and ADAMTS4 was assayed by western blot and quantification.</div>

Mediators of Inflammation

fig5

Figure 5

Figure 5: Inverse Agonist of Retinoid-Related Orphan Receptor-Alpha Prevents Apoptosis and Degeneration in Nucleus Pulposus Cells via Upregulation of YAP 

Figure 5 | Inverse Agonist of Retinoid-Related Orphan Receptor-Alpha Prevents Apoptosis and Degeneration in Nucleus Pulposus Cells via Upregulation of YAP 