The Modulation of Interferon Regulatory Factor-1 via Caspase-1-Mediated Alveolar Macrophage Pyroptosis in Ventilator-Induced Lung Injury

Figure 3

Caspase-1 deletion abolishes VILI and cytokine release in mice. Caspase-1 deletion alleviated the high-tidal-volume ventilation-induced lung injury measured by lung injury scores (d) for lung pathology. (a) Lung gross pathology is shown. Representative histologic sections for lung pathology (b) (magnification, 20×) and (c) (magnification, 400×) are shown. Caspase-1 deletion alleviated lung pathology in gross pathology (a) and HE-stained micrographs (b and c). Caspase-1 deletion reduced the wet/dry (W/D) ratio (e) and BALF protein concentration (f) in the high VT group. Caspase-1 deletion attenuated the release of IL-6 (g) and TNF-α (h) in BALF of high VT. Results are representative of three independent experiments; the results of one representative experiment are shown (/group, , ).

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