Cayratia japonica Prevents Ulcerative Colitis by Promoting M2 Macrophage Polarization through Blocking the TLR4/MAPK/NF-κB Pathway

Figure 1

Pharmacological analysis of key targets of CJ in UC. (a) 3D pharmacophore of rutin, chlorogenic acid, and quercetin retrieved from the PubChem database. (b) Volcano map of differentially expressed targets in dataset GSE48958 (control ; UC ). Red dots represent the upregulated genes. Green dots represent downregulated genes. (c) Volcano map of the differentially expressed targets in the dataset GSE65114 (control ; UC ). (d) Venn map showing the intersection of differentially expressed targets from the datasets GSE48958 and GSE65114 and the drug targets. (e) PPI network of 60 candidate targets. (f) Top 15 targets with highest degree values displayed in the PPI network. (g) The “drug-component-target” network map. (h) KEGG enrichment analysis of the 60 candidate targets. The targets are shown in the left while the pathways are shown in the right. Counterclockwise direction starting from RELA indicates less pathway enrichment.

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