Mitochondrial Transplantation Promotes Remyelination and Long-Term Locomotion Recovery following Cerebral Ischemia

<div>Restoration of mitochondrial function in ischemic cortex by exogenous mitochondria. (a) Mitochondrial complex activity in control and mitochondria-treated cortex. (b) ATP levels in control and mitochondria-treated cortex. (c) Combination of NG2 and CNPase staining with Mito-Tracker (Mito) labeling in ischemic cortex at 24 h and 3 d posttransplantation. Images in the frames were magnified. Notice the internalized mitochondria by NG2- and CNPase-positive cells. Notice the increase of mitochondrial complex activity and ATP level in mitochondria-treated mice. One way ANOVA for (a). Student’s t test for (b). <svg height="8.32035pt" id="M8" style="vertical-align:-0.2063999pt" version="1.1" viewbox="-0.0498162 -8.11395 27.8368 8.32035" width="27.8368pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M495 86L479 114C446 82 419 66 409 66C401 66 401 72 406 97C420 166 436 231 453 297C489 435 454 448 428 448C406 448 384 439 354 422C305 394 222 327 161 247H159L183 345C200 415 194 448 173 448C143 448 82 410 23 351L38 325C64 349 95 371 105 371C111 371 116 365 109 336L25 -4L31 -12C50 -4 77 3 107 9C119 69 132 122 145 168C197 254 321 381 370 381C387 381 393 374 378 305L329 95C309 17 320 -12 345 -12C372 -12 430 19 495 86Z"></path></g><g transform="matrix(.013,0,0,-0.013,10.158,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z"></path></g><g transform="matrix(.013,0,0,-0.013,21.421,0)"><path d="M153 550H386L412 615L406 623H120L82 318C104 327 142 338 184 338C294 338 347 275 347 187C347 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Mediators of Inflammation

fig1

Figure 1

Figure 1: Mitochondrial Transplantation Promotes Remyelination and Long-Term Locomotion Recovery following Cerebral Ischemia 