Research Article
Vericiguat Modulates Osteoclast Differentiation and Bone Resorption via a Balance between VASP and NF-κB Pathways
Figure 1
Molecular structure and cytotoxicity of Vericiguat on bone marrow-derived monocyte-macrophage lineage (BMMs). (a) Molecular structure of Vericiguat; (b) BMM cell viability as detected by CCK-8 assay after treatment with indicated concentrations of Vericiguat for 24 h. Data are presented as (). (c) The IC50 values of Vericiguat against BMMs. (d, e) The effect of Vericiguat on apoptosis-related markers, Bax and Bcl-2, in BMMs and quantitative results (). indicated a comparison with the control group (0 nM): , , , and .
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