Vericiguat Modulates Osteoclast Differentiation and Bone Resorption via a Balance between VASP and NF-κB Pathways

Figure 2

Vericiguat dually regulated RANKL-triggered osteoclast formation in vitro. (a) Representative images of TRAP-positive osteoclasts (red circles) after stimulation with RANKL and indicated concentrations of Vericiguat (). Image was used as the negative control (BMMS without RANKL). (b) The number and the size of TRAP⁺ multinucleated osteoclasts were quantified. means three independent experiments. indicated a comparison with the control group (without RANKL and Vericiguat): , , , and . # indicated a comparison between the group with RANKL only and the group with RANKL and Vericiguat: ^#, ^##, ^###, and ^####. ns: not statistically significant. .

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