Vericiguat Modulates Osteoclast Differentiation and Bone Resorption via a Balance between VASP and NF-κB Pathways

Figure 3

Vericiguat dually regulated the formation of F-actin ring and bony resorption of osteoclasts. (a) Representative images of F-actin-stained osteoclasts under the stimulation of RANKL for 7 d with 500 nM and 8 μM Vericiguat, respectively. (b) The average number and area of F-actin ring (c) (). (d) Representative images of bony resorption (white area circled by a red dotted line) by mature osteoclasts. (e) The bony resorption area was quantified. Values are presented as the (). indicated a comparison with the control group (Vericiguat, 0 nM): , , , and . .

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