MicroRNA-29b Suppresses Inflammation and Protects Blood-Brain Barrier Integrity in Ischemic Stroke

<div>Neutrophilic miR-29b levels are significantly lower in stroke patients and show strong diagnostic value. (a) The number and percentage of neutrophils in stroke patients. (b) miR-29b levels in neutrophils of stroke patients. Receiver operating characteristic (ROC) curve of miR-29b in diagnosing ischemic stroke. (c) Correlation between miR-29b expression and National Institute of Health Stroke Scale (NIHSS) score at admission. (d) C1QTNF6 mRNA levels in neutrophils of ischemic stroke patients. (e) Correlation between miR-29b and C1QTNF6 expression at admission. The predicted binding sites between miR-29b and C1QTNF6. <svg height="8.8423pt" id="M29" style="vertical-align:-0.2064009pt" version="1.1" viewbox="-0.0498162 -8.6359 38.4976 8.8423" width="38.4976pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M822 650H589L583 622C660 617 677 607 674 561C672 534 664 481 647 390L600 137H596L273 650H126L120 622C176 620 194 615 207 594C221 571 225 557 214 504L161 257C141 166 129 112 121 85C108 42 83 30 29 28L23 0H260L266 28C193 33 173 42 176 89C178 122 186 172 202 255L256 527H259L583 -8H612L690 390C708 481 720 535 728 558C744 603 756 619 816 622L822 650Z"></path></g><g transform="matrix(.013,0,0,-0.013,14.542,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z"></path></g><g transform="matrix(.013,0,0,-0.013,25.805,0)"><path d="M137 343C167 482 260 545 321 574C357 591 397 603 429 609L423 641C382 634 335 622 295 608C189 570 37 457 37 238C37 84 125 -12 242 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d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> vs. control group. AUC indicates area under the ROC curve.</div>

Mediators of Inflammation

fig1

Figure 1

Figure 1: MicroRNA-29b Suppresses Inflammation and Protects Blood-Brain Barrier Integrity in Ischemic Stroke 