CD226 Deficiency Alleviates Murine Allergic Rhinitis by Suppressing Group 2 Innate Lymphoid Cell Responses

Figure 5

CD226 deficiency reduced the proportion of ILC2 in the nasal mucosa in AR. (a) Mononuclear cells were isolated from the nasal mucosa of WT and Cd226 KO mice. The proportion of ILC2s (Lin⁻ CD45⁺ ST2⁺ KLRG1⁺) among Lin⁻ CD45⁺ cells (). (b) Representative images of immunofluorescence staining with ST2 and Thy-1 antibodies. ILC2s were positively stained for both ST2 and Thy-1. The white arrows represent ILC2s. Each experiment was repeated three independent times.  μm. (c, d) The proportions of (c) IL-5⁺ and (d) IL-13⁺ cells in ILC2s (). AR: allergic rhinitis; OVA: ovalbumin; NS: normal saline; ILC2s: type 2 innate lymphoid cells; WT: wild type; KO: knockout. , , and .

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