Knockdown of LMX1B Suppressed Cell Apoptosis and Inflammatory Response in IL-1β-Induced Human Osteoarthritis Chondrocytes through NF-κB and NLRP3 Signal Pathway

Figure 1

LMX1B was upregulated in OA cartilage tissue and IL-1β-induced chondrocytes. (a, c, and e) qRT-PCR analysis for LMX1B mRNA expression in cartilage tissue (a), SW1353 cells (c), and C28/I2 cells (e). (b, d, and f) Western blot analysis for LMX1B protein expression in cartilage tissue (b), SW1353 cells (d), and C28/I2 cells (f). SW1353 and C28/I2 cells were treated with 10 ng/ml IL-1β for 24 h. . 20 OA patients and 10 normal subjects were used in this study; moreover, all experiments were repeated three times in SW1353 and C28/I2 cells.

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