Treatment with <i>Commelina communis</i> Extract Exerts Anti-inflammatory Effects in Murine Macrophages via Modulation of the Nuclear Factor-<i>κ</i>B Pathway

<div><i>Commelina communis</i> extract (CCE) treatment restricts nitric oxide (NO) production in lipopolysaccharide- (LPS-) exposed RAW 264.7 cells. (a) Cytotoxicity, (b) viability, and (c) NO levels of murine macrophages. Murine macrophages were treated with 100 ng/mL LPS. The cytotoxicity and cellular viability were measured using MTT assay, and NO levels were evaluated using Griess reaction. Data were compared between groups using Student’s <span class="nowrap"><svg height="8.02022pt" id="M38" style="vertical-align:-0.2063999pt" version="1.1" viewbox="-0.0498162 -7.81382 4.54925 8.02022" width="4.54925pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M324 430H196L233 583L223 592L145 529L120 430H54L29 396L31 388H111L56 126C33 15 54 -12 77 -12C137 -12 214 57 250 95L233 119C208 92 155 59 138 59C126 59 120 70 131 125L186 390L298 394L324 430Z"></path></g></svg>-</span>test and one-way analysis of variance. The results are expressed as the <svg height="9.65783pt" id="M39" style="vertical-align:-0.3499298pt" version="1.1" viewbox="-0.0498162 -9.3079 139.147 9.65783" width="139.147pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M797 0V26C739 32 732 36 732 103V296C732 394 682 449 605 449C576 449 550 437 529 423C504 407 475 389 446 366C425 418 382 449 334 449C303 449 279 437 253 421C222 403 201 385 180 371V452C135 432 85 419 41 411V388C99 379 102 374 102 310V103C102 38 93 32 27 26V0H238V26C189 32 180 38 180 103V338C210 363 250 390 289 390C351 390 377 348 377 275V103C377 37 368 32 306 26V0H520V26C465 32 456 38 456 101V296C456 314 455 326 453 338C491 369 529 390 565 390C628 390 653 345 653 274V107C653 36 642 32 583 26V0H797Z"></path></g><g transform="matrix(.013,0,0,-0.013,10.595,0)"><path d="M380 106C343 72 306 56 265 56C195 56 116 112 115 248C235 252 361 262 377 265C396 269 400 277 400 297C400 374 333 449 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Mediators of Inflammation

fig2

Figure 2

Figure 2: Treatment with <i>Commelina communis</i> Extract Exerts Anti-inflammatory Effects in Murine Macrophages via Modulation of the Nuclear Factor-<i>κ</i>B Pathway 

Figure 2 | Treatment with Commelina communis Extract Exerts Anti-inflammatory Effects in Murine Macrophages via Modulation of the Nuclear Factor-κB Pathway 