Interleukin-27 Ameliorates Atherosclerosis in ApoE^-/- Mice through Regulatory T Cell Augmentation and Dendritic Cell Tolerance

Figure 1

Recombinant IL-27 inhibited the initiation of atherosclerosis. (a), (b), and (c), Representative photomicrographs show Oil Red O and hematoxylin stained aortic root sections from groups treated with IL-27, anti-IL-27p28-Ab, or PBS while they were fed a high-fat diet for 8 weeks, respectively. (g) Data from group (a), (b), and (c) are shown. A black bar represents 200 μm. (d), (e), and (f) Representative photomicrographs show Oil Red O stained the descending aortas from groups treated with IL-27, anti-IL-27p28-Ab, or PBS while they were fed a high-fat diet for 8 weeks, respectively. (h) Data from group (d), (e), and (f) are shown. , , .

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