Interleukin-27 Ameliorates Atherosclerosis in ApoE<sup>-/-</sup> Mice through Regulatory T Cell Augmentation and Dendritic Cell Tolerance

<div>Recombinant IL-27 elevated the generation of Foxp3<sup>+</sup> and LAP<sup>+</sup> Tregs in the blood of ApoE<sup>-/-</sup> mice. (a) In the blood, the fractions of Foxp3<sup>+</sup> and LAP<sup>+</sup> Tregs were measured by flow cytometry. (A) and (B) show the fractions of Foxp3<sup>+</sup> Tregs (A) and LAP<sup>+</sup> Tregs (B) during the initiation of atherosclerosis. (C) and (D) show the fractions of Foxp3<sup>+</sup> Tregs (C) and LAP<sup>+</sup> Tregs (D) during the progression of atherosclerosis. 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Mediators of Inflammation

fig4

Figure 4

Figure 4: Interleukin-27 Ameliorates Atherosclerosis in ApoE<sup>-/-</sup> Mice through Regulatory T Cell Augmentation and Dendritic Cell Tolerance 

Mediators of Inflammation

Interleukin-27 Ameliorates Atherosclerosis in ApoE-/- Mice through Regulatory T Cell Augmentation and Dendritic Cell Tolerance

Figure 4

Interleukin-27 Ameliorates Atherosclerosis in ApoE^-/- Mice through Regulatory T Cell Augmentation and Dendritic Cell Tolerance