Continuous Theta-Burst Stimulation Promotes Paravascular CSF-Interstitial Fluid Exchange through Regulation of Aquaporin-4 Polarization in APP/PS1 Mice

Figure 3

CTBS promotes glymphatic clearance in APP/PS1 mice. (a) In vivo two-photon imaging of tracer clearance through the glymphatic pathway in 10 min, 15 min, 30 min, 45 min, and 60 min in AS and AR groups (250×, scale bar: 200 μm). (b) Statistical quantification of CSF tracer influx into the paravascular space. (c) Statistical quantification of CSF tracer penetration into the surrounding parenchyma. Data are presented as the ( mice per group, two-way ANOVA with Tukey’s test for multiple comparisons; , , , and ).

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