Identification of an Epigenetic Signature for Coronary Heart Disease in Postmenopausal Women’s PBMC DNA

Figure 3

Methylation levels differed across groups. (a) A volcano plot of PC vs. PCG probe-level methylation. (b) A volcano plot of methylation at the probe level in PC vs. C. The graph depicts the link between the amount of the difference in values (Δβ values; -axis) and the number of values (negative log10 transformed values; -axis). A single probe is represented by each dot. Horizontal and vertical dashed lines represent the and 10% methylation difference (=0.1) cutoffs, respectively. Hyper- and hypomethylated DMPs are represented by orange and blue dots, respectively. (c) A heat map of the top 5000 differentially methylated CpG sites in the PC versus PCG groups. (d) Heat map of PC vs. C group’s top 5000 differentially methylated CpG sites. The heat map’s orange color shows loci that have been hypermethylated, while the heat map’s blue color shows loci that have been hypomethylated.

(a)

(b)

(c)

(d)