Identification of an Epigenetic Signature for Coronary Heart Disease in Postmenopausal Women’s PBMC DNA

Figure 4

Differentially methylated positions are located on genomic CpG islands. (a) Distribution of methylated positions with respect to genomic regions in the PC vs. PCG group. (b) The distribution of methylated positions in the PC vs. PCG groups in relation to CpG island features. (c) Distribution of methylated positions with respect to genomic regions in the PC vs. C group. (d) The distribution of methylated positions in the PC vs. C groups in relation to CpG island features. 1stExon: first exon; TSS: transcription start site; TSS1500 and TSS200: 1500 bp and 200 bp downstream of the TSS, respectively; UTR: untranslated region. Island, probes located on CpG islands; open sea, probes not located on an island or annotated genes; shelf, probes located more than 2 k from CpG islands; and shore, probes located less than 2 kb from a CpG island.

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