Identification of an Epigenetic Signature for Coronary Heart Disease in Postmenopausal Women’s PBMC DNA

Figure 7

The core gene interaction network diagram was analyzed using a functional epigenetic module (FEM). In the FEM study, FOXA2 and FBN2 were shown to be the module’s seed genes. (a) and (b) are the key gene results of PC vs PCG, while (c) and (d) represent the key gene results of PC vs. C. The protein–protein interaction (PPI) network defines the connection between each node in the diagram. The value of differential methylation determines the node’s color. It will be yellow to white if is less than 1.5 and light blue to blue with gray in the center if it is larger than 1.5.

(a)

(b)

(c)

(d)