Inhibition of CEBPB Attenuates Lupus Nephritis via Regulating Pim-1 Signaling

Figure 6

CEBPB regulated the activation of NLRP3 inflammasomes in glomerular podocytes via the regulation of Pim-1. The mRNA expression level of Pim-1 in CEBPB knockdown podocytes (a); the binding of Pim-1 promoter and CEBPB detected by chromatin immunoprecipitation (b) and dual-luciferase reporter assay (c); the transfect efficiency of Pim-1 overexpression (d); the content of IL-1β (e) and IL-6 (f) in the cell supernatant; Protein expression of key proteins in the inflammasome-related signaling pathway (g, h). (CEBPB, CCAAT/enhancer-binding protein β).

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