Candesartan Reduces Neuronal Apoptosis Caused by Ischemic Stroke via Regulating the FFAR1/ITGA4 Pathway

Figure 4

Compound-genomics target drug prediction and functional analysis. (a) Prediction of compound targeting FFAR1 was analyzed by PubChem (https://pubchem.ncbi.nlm.nih.gov). (b) Target prediction of candesartan was analyzed by SwissTargetPrediction (http://www.swisstargetprediction.ch/), and the top 25 targets were classified to obtain the target class pie chart. (c) Then, Venn analysis (http://bioinformatics.psb.ugent.be/webtools/Venn/) of the compound targets (100 genes) with profile 22 (359 genes) was performed. (d) The correlation between gene expression and time of the intersection genes was analyzed by Venn analysis. (e) Bar graph of enriched terms across input gene lists by Metascape (https://metascape.org/gp/index.html#/main/step1). (f) Network of enriched terms. (g, h) Protein-protein interaction network and MCODE components were identified in the gene lists. (i) Enrichment analysis of the input gene was listed by Enrichr (https://maayanlab.cloud/Enrichr/).

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