Curcumin Targeting NF-κB/Ubiquitin-Proteasome-System Axis Ameliorates Muscle Atrophy in Triple-Negative Breast Cancer Cachexia Mice

Figure 8

Curcumin treatment reduces ubiquitination and NF-κB activity in muscle tissue of tumor-bearing mice. (a–c) Statistical analysis of atrogin-1, MuRF-1, and NF-κB mRNA expression of mouse gastrocnemius in three groups. (d) Western blot bands of atrogin-1 and MuRF-1 protein in gastrocnemius of the three groups. (e) Western blot bands of P65 and P-P65 protein in gastrocnemius of the three groups. (f–i) Statistical analysis of atrogin-1, MuRF-1, P-65, and PP-65 protein expressions in gastrocnemius of three groups of mice. NS: not significant; , , and by -test, compared to the model group. Data was shown as .

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