Research Article
Targeting NLRP3 Inflammasome Alleviates Synovitis by Reducing Pyroptosis in Rats with Experimental Temporomandibular Joint Osteoarthritis
Figure 2
Elevated expression of molecules in TMJ synovium. (a, b) Western blotting results of NLRP3, ASC, cleaved caspase-1, IL-1β, and GSDMD in the sham and OA synovitis rats. (c) mRNA levels of NLRP3, ASC, caspase-1, IL-1β, and GSDMD expressed in TMJ synovium between the sham and OA rats. (d) Immunohistochemistry of TMJ slices from the sham or OA rats using anti-NLRP3, anti-caspase-1, anti-GSDMD, and anti-IL-1β antibodies, scale μm. Positive cells are mainly around synovial membrane and vessels (black arrow). (e) Percentage of positive cells. Data in this figure are analyzed by independent samples -test and presented as . , , and .
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