Rapamycin Alleviates 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis through Autophagy Induction and NF-κB Pathway Inhibition in Mice

Figure 1

Rapamycin protects against TNBS-induced colitis in mice. (a) After being treated with TNBS (100 μl of 2.0%), mice were gavaged with rapamycin (3 mg/kg/day) or saline (100 μl) for 7 days. Disease activity index (DAI) scores were used to evaluate the severity of colitis. The DAI was determined by scoring changes in weight, hemoccult positivity, or blood trace and stool consistency. TNBS vs. control; ^#TNBS+Rapa vs. TNBS+saline. . (b) H&E staining was used to examine the histological changes of colonic mucosa (×100). (c) The histological scores were calculated to evaluate the severity of colonic mucosa inflammation ( per group, ).

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