Research Article
Methylation Mediated Silencing of miR-155 Suppresses the Development of Preeclampsia In Vitro and In Vivo by Targeting FOXO3
Figure 1
Inflammatory response and upregulated miR-155 expression are observed in PE patients. (a) IL-6, IL-8, and TNF-α in the serum derived from 20 cases of PE and 20 cases of non-PE samples were detected using enzyme-linked immuno-sorbent assay. (b) miR-155 expression in the placental tissues of PE patients or normal placental tissues determined by RT-qPCR (). (c) A schematic drawing shows CpG sites in the miR-155 gene promoter and BSP assay location. Each vertical bar represents a CpG site (12 sites). (d) miR-155 expression was inversely correlated with its promoter methylation level in 20 cases of PE and 20 age-matched non-PE samples. , and .
(a) |
(b) |
(c) |
(d) |