Research Article
Methylation Mediated Silencing of miR-155 Suppresses the Development of Preeclampsia In Vitro and In Vivo by Targeting FOXO3
Figure 5
miR-155 knockdown increased cell viability, migration, and invasion in trophoblast cells by upregulating FOXO3. HTR8/SVneo and JEG-3 cells were transfected with NC, inhibitor, si-NC, si-FOXO3, and inhibitor + si-FOXO3, respectively. (a) Cell viability was evaluated by CCK-8 assay in the above-transfected cells. (b) Detection of cell apoptosis by TUNEL assay. Transwell assay was used to analyze cell migration (c) and invasion (d) in the above-transfected cells. , and .
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