ST3GAL3 Promotes the Inflammatory Response of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Activating the TLR9/MyD88 Pathway

<div>ST3GAL3 regulated the TLR9/MyD88 signalling pathway. (a) GSEA software was used to analyse the enrichment signalling pathways associated with <i>ST3GAL3</i> in RA. TLR signalling pathway was finally screened out. (b) Western blotting results showed that ST3GAL3 overexpression promoted the expression of TLR9 and MyD88. (c) Western blotting results showed that si-ST3GAL3 inhibited the expression of TLR9 and MyD88. (d) Western blotting result showed that si-ST3GAL3 inhibited sLeX levels in MH7A cells. (e) Western blotting result showed the activated TLR9/MyD88 signalling pathway by adding with sLeX in MH7A cells. 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Mediators of Inflammation

fig5

Figure 5

Figure 5: ST3GAL3 Promotes the Inflammatory Response of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Activating the TLR9/MyD88 Pathway 