ST3GAL3 Promotes the Inflammatory Response of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Activating the TLR9/MyD88 Pathway

<div>ST3GAL3 promoted the proliferation and migration of MH7A cells by activating the TLR9/MyD88 pathway. (a) The sequences of CpG-ODNs (CpG 2216 and CpG 2006). (b) MTT assay results showed that transfection of MH7A cells with si-TLR9 reversed the effects of ST3GAL3 on cell proliferation. (c) MTT assay results showed that adding with CpG-ODNs reversed the effects of si-ST3GAL3 on MH7A cell proliferation. (d) Representative images of cell migration from transwell assay. (e) Transwell assay results showed that transfection of MH7A cells with si-TLR9 reversed the effects of ST3GAL3 on cell migration. (f) Transwell assay results showed that adding with CpG-ODNs reversed the effects of si-ST3GAL3 on MH7A cell migration. <span class="nowrap"><svg height="8.55521pt" id="M62" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -8.34882 27.8368 8.55521" width="27.8368pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M495 86L479 114C446 82 419 66 409 66C401 66 401 72 406 97C420 166 436 231 453 297C489 435 454 448 428 448C406 448 384 439 354 422C305 394 222 327 161 247H159L183 345C200 415 194 448 173 448C143 448 82 410 23 351L38 325C64 349 95 371 105 371C111 371 116 365 109 336L25 -4L31 -12C50 -4 77 3 107 9C119 69 132 122 145 168C197 254 321 381 370 381C387 381 393 374 378 305L329 95C309 17 320 -12 345 -12C372 -12 430 19 495 86Z"></path></g><g transform="matrix(.013,0,0,-0.013,10.158,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z"></path></g><g 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Mediators of Inflammation

fig6

Figure 6

Figure 6: ST3GAL3 Promotes the Inflammatory Response of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Activating the TLR9/MyD88 Pathway 