Research Article
Treatment with Herbal Formula Extract in the hSOD1G93A Mouse Model Attenuates Muscle and Spinal Cord Dysfunction via Anti-Inflammation
Figure 4
Herbal formula extract (HFE) regulated expression of autophagy- and muscle atrophy-related proteins in hSOD1G93A mice. (a) Representative immunoblots and quantification of autophagy-related proteins (p62 and LC3b) and muscle atrophy-related proteins (TGF-β and SMAD2) in the tibialis anterior (TA) (b) and gastrocnemius (GC) (c, e) of each group. =3–4 mice per group. (d) mRNA level of muscle denervation-related genes (Myo and Churg) in each group. =3–5 per group. Data are presented as the mean ± SEM. , , . nTg: nontransgenic mice, Tg: transgenic mice, Tg + HFE: HFE-treated transgenic mice.
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