Comprehensive Analysis and Functional Characteristics of Differential Expression of N6-Methyladenosine Methylation Modification in the Whole Transcriptome of Rheumatoid Arthritis

Figure 5

Selection and clinical validation of m6A-modified target genes. (a) Peaks of the upregulated m6A-modified target genes. (b) Peaks of the downregulated m6A-modified target genes. (c) Target genes of m6A modification were detected by RT-PCR. , , (, paired -test). (d) Protein expression of m6A modification was detected by western blot. (, paired -test). (e) Macrophage marker expression. (, paired -test). (f) Correlational analysis of m6A-modified target genes and RF. (g) Correlational analysis of m6A-modified target genes and CCP. (h) ROC curve analysis of m6A-modified target genes in RA.

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