Comprehensive Analysis and Functional Characteristics of Differential Expression of N6-Methyladenosine Methylation Modification in the Whole Transcriptome of Rheumatoid Arthritis

Figure 6

m6A-modified inflammatory signaling pathway is expressed in vivo. (a) Dynamic changes of joint swelling in rats. (b) Comparison of toe swelling and arthritis index. , vs NC group (paired -test). (c) Safranin fast-green staining of joints, X400. (d) Comparison of the expression of cytokines secreted by macrophages., (paired -test). (E) Comparison of the MAPK, PI3K, and AKT inflammatory signaling pathway-related indicators. , (paired -test). (f) Comparison of the p-MAPK, p-PI3K, p- AKT1, and p-PTEN., (, paired -test). (g) Correlational analysis of signaling pathway-related indicators and joint inflammation.

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