Predictive Role of IL-2R and IL-10 in the Anti-inflammatory Response and Antiplatelet Therapy of Kawasaki Disease: A Retrospective Study

Figure 1

Effect of IVIG on the inflammatory response in children with KD under different conditions. (a) There was no significant difference in the NLR before IVIG between the group of patients with KD who were <4 years old and the group of patients who were ≥4 years old. (b) The NLR after IVIG in children with KD who were ≥4 years old was markedly higher than that in children with KD who were <4 years old. . (c) No significant difference in the ratio of IL-2R/IL-10 before IVIG was observed between children with KD who were ≥4 years old and children with KD who were <4 years old. (d) The ratio of IL-2R/IL-10 after IVIG was lower in children with KD who were ≥4 years old than in children with KD who were <4 years old. . (e) In children with KD who were <4 years old, the ratio of IL-2R/IL-10 increased significantly after IVIG () and was higher than that before IVIG (). . (f) In children with KD who were ≥4 years old, the ratio of IL-2R/IL-10 increased after IVIG () and was higher than that before IVIG (). . CD: cluster of differentiation; IL: interleukin; IVIG: intravenous immunoglobulin; KD: Kawasaki disease; NLR: neutrophil and lymphocyte ratio; ns: not significant; y: years.

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