Predictive Role of IL-2R and IL-10 in the Anti-inflammatory Response and Antiplatelet Therapy of Kawasaki Disease: A Retrospective Study
Table 1
Clinical and biochemical characteristics of the Kawasaki disease children.
Characteristics
Value
value
Patients,
64
—
Sex (male), (%)
41 (64)
0.31a
Age, years
3.21 (1.25-4.75)
—
Body weight, kg
15.75 (11.00-18.11)
—
NLR before IVIG (<5.0)b
2.97 (1.74-5.65)
—
NLR after IVIG (<5.0)b
0.64 (0.36-1.19)
—
Percentage of CD19+ B cells before IVIG (NR, 6.8-15.8%)
25.46 (20.91-37.40)
<0.05
Percentage of CD8+ T cells before IVIG (NR, 18.2-32.8%)
<0.01
Levels of IL-10 before IVIG, pg/ml (<9.1)
13.30 (6.02-38.88)
—
Levels of IL-10 after IVIG, pg/ml (<9.1)
4.9 (4.9-5.21)
—
Extent of decreased IL-10, pg/ml
6.80 (1.01-33.98)
—
Levels of IL-2R before IVIG, U/ml (223-710)
1705.50 (1109.00-2923.75)
<0.001
Levels of IL-2R after IVIG, U/ml (223-710)
1337.00 (881.25-1870.0)
<0.001
Extent of decreased IL-2R, U/ml
455.0 (130.75-1053.25)
—
aCompared with the data reported in the 2020JCS guide [1]. best according to the study published [14]. Data are presented as the , number, or median (QL-QU). CD: cluster of differentiation; IL: interleukin; IVIG: intravenous immunoglobulin; NR: normal range; NLR: neutrophil lymphocyte ratio.
