Review Article

Neutrophil to Lymphocyte Ratio in Epilepsy: A Systematic Review

Table 1

General characteristics of included studies.

First authorYearRegionDesignSample sizeMean ageGender (percentage of males)Main result

Aslan [25]2020TurkeyRetrospectiveTotal: 170
Patients: 113
Controls: 57
Patients:
Controls:
Patients: 55 (48.7%)
Controls: 32 (56.1%)
There was significantly higher NLR in epileptic patients compared to the healthy controls.
Baran [24]2020TurkeyRetrospectiveTotal: 71
Patients: 36
Controls: 35
Patients:
Controls:
Patients: 20 (55.5%)
Controls: 19 (54.28%)
NLR was not significantly different between patients and healthy controls.
Güneş [23]2020TurkeyRetrospectiveTotal: 144
Patients: 72
Controls: 72
Patients:
Controls:
Patients: 35 (48.6%)
Controls: 36 (50%)
The probability of epileptic seizure increased 1.954 times for every unit rise in NLR during the acute phase and 1.731 times for every unit rise in NLR during the subacute phase.
Özdemir [13]2016TurkeyRetrospectiveTotal: 116
Patients: 58
Controls: 58
Patients:
Controls:
Patients: 26 (44.8%)
Controls: 31 (53.4%)
NLR was not significantly different between patients with convulsive status epilepticus and healthy controls.
Morkavuk [4]2020TurkeyProspectiveTotal: 50
Epilepsy: 36
PNES: 14
Epilepsy patients: 26.5 (18.5-48.3)
PNES group: 33.5 (18–56)
Epilepsy patients: 23 (64%)
PNES group: 4 (29%)
NLR is not a good biomarker for differentiating between patients with epileptic seizures and those with pseudoseizures.
Ozdemir [26]2019TurkeyProspectiveTotal: 42
Patients: 21
Controls: 21
Patients:
Controls:
Patients: 9 (42%)
Controls: 13 (61%)
Surgery for temporal lobe epilepsy resulted in large increases in NLR, and NLR was significantly higher after surgery compared to before surgery samples of patients.
Eroglu [27]2017TurkeyRetrospectiveTotal: 101
Patients: 52
Controls: 49
Patients:
Controls:
Patients: 20 (38.5%)
Controls: 19 (38.8%)
NLR was not significantly different between patients and healthy controls.

PNES: psychogenic nonepileptic seizures; NLR: neutrophil to lymphocyte ratio.