Cordycepin Protects against Hepatic Ischemia/Reperfusion Injury via Inhibiting MAPK/NF-κB Pathway

Figure 3

Cordycepin reduced systemic inflammatory responses induced by hepatic IR. Note: (a) western blot analysis of TNF-α, IL-6, and IL-1β protein levels. (b) Relative TNF-α, IL-6, and IL-1β levels were determined by qRT-PCR. (c) TNF-α, IL-6, and IL-1β protein expressions in liver tissues after reperfusion are shown by immunohistochemical staining (×200). The evaluations were made by the Image-Pro Plus 6.0 software to calculate the IOD of the positive staining area. Data are presented as (; # for IR vs. sham; + for L-cordycepin (25 mg/kg) vs. IR; for H-cordycepin (50 mg/kg) vs. IR; ! for L-cordycepin (25 mg/kg) vs. H-cordycepin (50 mg/kg)).

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