Cordycepin Protects against Hepatic Ischemia/Reperfusion Injury via Inhibiting MAPK/NF-κB Pathway

Figure 5

The protective effect of cordycepin on HIRI in mice was related to MAPK/NF-κB signaling pathway. Note: (a) western blot analysis of MAPK, p-MAPK, and NF-κB protein levels. (b) Relative NF-κB levels were determined by qRT-PCR. (c) p-MAPK and NF-κB protein expressions in liver tissues after reperfusion are shown by immunohistochemical staining (×200). The evaluations were made by the Image-Pro Plus 6.0 software to calculate the IOD of the positive staining area. Data are presented as (; # for IR vs. sham; + for L-cordycepin (25 mg/kg) vs. IR; for H-cordycepin (50 mg/kg) vs. IR; ! for L-cordycepin (25 mg/kg) vs. H-cordycepin (50 mg/kg)).

(a)

(b)

(c)