Cordycepin Protects against Hepatic Ischemia/Reperfusion Injury via Inhibiting MAPK/NF-κB Pathway

Figure 6

Possible mechanism of cordycepin in hepatic ischemia-reperfusion injury. In IR model, activated Kupffer cells promote the release of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6, and cordycepin reduces inflammatory cytokines. In addition, cordycepin inhibited the phosphorylation of MAPK, which then reduce the expression of NF-κB to effect hepatocyte apoptosis and autophagy. Cordycepin has a protective effect on ischemia-reperfusion liver by inhibiting inflammation and attenuating apoptosis and autophagy through the MAPK/NF-κB pathway.