Hepatoprotective Role of 4-Octyl Itaconate in Concanavalin A-Induced Autoimmune Hepatitis

<div>OI reduced Con A-induced macrophage infiltration and expression of proinflammatory cytokines in mice. (a) Representative immunofluorescence micrographs showed that the F4/80-positive cells in each group and the (b) positive cells in each group were evaluated. (c, d) Immunofluorescence for CD4-positive staining cells of the liver tissue. The serum levels of proinflammatory cytokines including (e) TNF-<i>α</i>, (f) IL-1<i>β</i>, (g) IL-6, and (h) IFN-<i>γ</i> were measured in each group. 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Mediators of Inflammation

fig2

Figure 2

Figure 2: Hepatoprotective Role of 4-Octyl Itaconate in Concanavalin A-Induced Autoimmune Hepatitis 