Hepatoprotective Role of 4-Octyl Itaconate in Concanavalin A-Induced Autoimmune Hepatitis

<div>Protective effect of OI was decreased by ML385 in Con A-induced liver injury. (a, b) Immunohistochemical assay of c-PARP was evaluated in hepatic tissues in each group. (c, d) The hepatocyte apoptosis was evaluated in hepatic tissues in each group by TUNEL assay. The (e) serum ALT and (f) serum AST activities were evaluated in each group in mice. To evaluate the oxidative stress, the (g) GSH/GSSG ratio and (h) MDA level were measured in each group. 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Mediators of Inflammation

fig5

Figure 5

Figure 5: Hepatoprotective Role of 4-Octyl Itaconate in Concanavalin A-Induced Autoimmune Hepatitis 