Hepatoprotective Role of 4-Octyl Itaconate in Concanavalin A-Induced Autoimmune Hepatitis

Figure 7

OI inhibited TNF-α, or supernatants from Con A-treated RAW264.7 cells induced hepatocyte apoptosis. (a, b) TNF-α significantly induced apoptosis in hepatocytes, whereas OI attenuated this change. RAW264.7 cells were treated with Con A and/or OI for 12 h, and the supernatants were added into AML12 cells for 24 h. Flow cytometry was used to detect (c, d) hepatocyte apoptosis, and the supernatants were collected to detect the levels of (e) IL-1β and (f) TNF-α. vs. control group; ^# vs. Con A or TNF-α group. Data are expressed as .

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