Pomiferin Exerts Antineuroinflammatory Effects through Activating Akt/Nrf2 Pathway and Inhibiting NF-κB Pathway

Figure 4

Effect of Pomiferin on Akt /Nrf2 pathway in BV2 cells. (a–c) BV2 cells were treated with LPS (100 ng/mL) and Pomiferin (1 μM) for 3 h. The effect of Pomiferin on Akt and Nrf2 pathways was detected by Western blot experiment. (d, e) Then, we treated BV2 cells with MK2206 (an Akt inhibitor, 10 μM) and BT (a Nrf2 inhibitor, 200 nM) for 6 h, and studied the effects of Pomiferin on ROS and NO after blocking Akt or Nrf2 pathway. Results were shown via (). ^## means significant difference with NT group. means significant difference with LPS group. ^&& means significant difference with LPS + Pomiferin group.

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