Using Network Pharmacology and Animal Experiment to Investigate the Therapeutic Mechanisms of Polydatin against Vincristine-Induced Neuropathic Pain

Table 2

The top 10 gene rank in cytoHubba.

	Rank methods in cytoHubba
	Radiality	MNC	EPC	DMNC	Degree	Closeness	Betweenness	Stress
Top 10 genes	IL-1β	IL-1β	IL-1β	BCL2	IL-1β	IL-1β	SQSTM1	SQSTM1
	IL-6	IL-6	IL-6	IL-1β	IL-6	IL-6	TP53	IL-1β
	TP53	TP53	TP53	SQSTM1	TP53	TP53	IL-6	TP53
	CXCL8	CXCL8	CXCL8	PTGS2	CXCL8	CXCL8	NQO1	IL-6
	CCND1	CCL2	CCL2	CXCL8	CCL2	CCL2	PARK7	NQO1
	RELA	RELA	RELA	CCL2	RELA	RELA	SOD2	PARK7
	TGFB1	IL-4	IL-4	IFNG	IL-4	IL-4	CCND1	CCND1
	MAPK1	MAPK1	MAPK1	IL-4	MAPK1	MAPK1	RELA	RELA
	MAPK3	MAPK3	MAPK3	CXCL10	MAPK3	MAPK3	MAPK1	MAPK1
	TNF	TNF	TNF	TNF	TNF	TNF	MAPK3	MAPK3