mTOR Modulates the Endoplasmic Reticulum Stress-Induced CD4⁺ T Cell Apoptosis Mediated by ROS in Septic Immunosuppression

Figure 2

Survival curves. Survival rates between CLP, CLP+NAC, CLP+C23, CLP+4-PBA, Lck-TSC1+CLP, and Lck-mTOR+CLP groups. During the first 18 hours after CLP operation, the survival conditions were regularly monitored every 2 hours and then observed every 6 hours. Median survival time of CLP was 64 h, and LCK-TSC1+CLP group was 56 h, while Lck-mTOR+CLP had a significantly prolonged median survival time of 104 h (Kaplan-Meier with log rank test). -14 mice per group. -axis: survival time; -axis: survival rate. P1 = LCK-TSC1+CLP vs. Lck-mTOR+CLP; P2 = CLP vs. Lck-mTOR+CLP. NAC = N-acetyl-L-cysteine; 4-PBA = sodium phenylbutyrate; C23 = CIRP-Ab; CIRP = cold-inducible RNA-binding protein.