The Role of Noncoding RNA in Airway Allergic Diseases through Regulation of T Cell Subsets

Figure 2

ncRNA regulates the mechanism of CD4⁺ T cell differentiation. ncRNA affects miRNA level via molecular sponge action, which can influence CD4⁺ T cell differentiation by binding to mRNA encoding CD4⁺ T cell genes, resulting in an imbalance between Th1 and Th2, Th17 and Treg. Thereby, exacerbating or reducing airway remodeling, inflammatory mediators release, and inflammatory responses.