|
ncRNA | Expression level | Signaling pathways or targets | Function |
|
miRNA-1248 | Upregulation | Unknown | Elevate Th2 cytokine levels [87] |
miRNA-126 | Upregulation | DNMT1 | Promote inflammation [88] |
miRNA-21 | Upregulation | PI3K/Akt, IL13Rα1, STAT6 | Modulate ASMCs proliferation, migration, and modulate IL-12 [89, 90] |
miRNA-21 | Upregulation | STAT4 | Decrease IL-12 levels [90] |
miRNA-98 | Upregulation | Unknown | Suppress the expression of TSP1 [91] |
miRNA-155 | Upregulation | PGE2 | Enhance COX2 expression [92] |
miR-371 miR-138 miR-544 miR-145 miR-214 | Upregulation | Runx3 | Balance Th1/Th2 [93] |
miRNA-16 | Upregulation | ADRB2 | Predictive biomarker of therapeutic response [94] |
miRNA-146a-5p | Upregulation | 5-LO | Attenuate inflammation [95] |
miRNA-30a | Upregulation | ATG5 | Decrease inflammation [96] |
miRNA-126 | Downregulation | GATA3 | Diminish Th2 response [32] |
miRNA-200 | Downregulation | Unknown | Inhibit IL-33 levels [35] |
miRNA-let-7a | Upregulation | Unknown | Decrease IL-33 levels [36] |
miR-192-5p | Upregulation | MMP-16, ATG7 | Enhance airway remodeling and autophagy [41] |
miR-19a | Upregulation | PTEN, MAPK/STAT1 | Enhance airway remodeling and Th2 [43, 44] |
miR-221-3p | Upregulation | CXCL17 | Aggravate inflammation [45] |
miRNA-221 | Downregulation | Unknown | Reduce airway inflammation [97] |
miR-142-3p | Downregulation | WNT | Regulate proliferation and differentiation of ASMCs [98] |
miRNA-34a | Downregulation | FoxP3 | Attenuate inflammation [99] |
miRNA-410 | Downregulation | Unknown | Decrease IL-4/IL13levels [100] |
miR-218-5p | Downregulation | CTNND2 | Suppress chemokine expression [101] |
miRNA-192 | Downregulation | CXCR5 | Suppresses T helper cell [102] |
miRNA-485 | Downregulation | TGF-β/Smads | Decrease smurf2 levels [103] |
miR-21-5p | Downregulation | Smad7 | Promote epithelial-mesenchymal transition [52] |
miR-301a-3p | Downregulation | STAT3 | Activate smooth muscle cells [53] |
lncRNA-MEG3 | Upregulation | miRNA-17/ RORγt | Regulate Treg/Th17 balance [62] |
lncRNA-MALAT1 | Upregulation | miRNA-155 | Promote Th2 inflammation [63] |
lncRNA PCGEM1 | Upregulation | NF-κB | Ameliorate inflammation [67] |
lncRNA CRNDE | Upregulation | Unknown | Enhance airway remodeling [73] |
lncRNA-BAZ2B | Upregulation | Unknown | Promote M2 macrophage activation [104] |
lncRNA-000127 | Upregulation | Unknown | Promote Th2 inflammation [105] |
lncRNA-TCF7 | Upregulation | TIMMDC1/Akt | Promote the growth and migration of ASMCs [106] |
lncRNA-PVT1 | Upregulation | miRNA-149, miR-15a-5p, miR-29c-3p | Exacerbate inflammation and impact Th1/Th2 imbalance [107, 108] |
lncRNA-PVT1 | Upregulation | miR-590-5p/FSTL1 | Attenuate airway remodeling [68, 109] |
lncRNA-ANRIL | Upregulation | miRNA-125a | Exacerbate severity and inflammation [69] |
lncRNA-Malat1 | Upregulation | miR-150-eIF4E/Akt | Exacerbate inflammation [110] |
lncRNA-NEAT1 | Upregulation | microRNA-124 | Increase inflammation [111] |
lncRNA- n337374 | Upregulation | CD86 and ERK | Ameliorate inflammation [112] |
lncRNA-BCYRN1 | Upregulation | Receptor potential 1 | Promote inflammation [113] |
lncRNA-TUG1 | Upregulation | microRNA181b/HMGB1 | Promote inflammation [114, 115] |
lncRNA- LASI | Upregulation | MUC5AC | Promote inflammation [115] |
lncRNA-H19 | Downregulation | PI3K/Akt/NF-kB, miR21/PTEN/Akt | Attenuate inflammation [116, 117] |
lncRNA-AK169641 | Downregulation | Unknown | Increase eosinophils infiltration [118] |
lncRNA-TUG1 | Downregulation | miR-29c/B7-H3 | Promote Th2 cell differentiation [20] |
lncRNA-AK085-865 | Downregulation | Unknown | Ameliorate inflammation [119] |
lncRNA-BCYRN1 | Downregulation | miRNA-150 | Inhibit the proliferation of ASMCs [113] |
lncRNA-LINCPINT | Downregulation | miRNA-265p/PTEN | Retard the abnormal growth of ASMCs [120] |
circRNA-0005519 | Upregulation | miRNA-7a-5p | Increase IL-6/IL-13levels [82] |
circRNA-HIPK3 | Upregulation | miR-326/STIM1; miR-375/MMP-16 | Modulate the proliferation of AMSCs [85, 121] |
circRNA-0002594 | Upregulation | Unknown | Upregulate in CD4+ T cells [86] |
CircRNA-ZNF652 | Upregulation | miR-452-5p/JAK2 | Promote the goblet cell metaplasia [122] |
circRNA-ERBB2 | Downregulation | miR-98-5p/IGF1R | Increase infiltration [123] |
|