|
| ncRNA | Expression level | Signaling pathways or target | Function |
|
| miRNA-223 | Upregulation | Unknown | Promote inflammation [130] |
| miRNA-155 | Upregulation | Unknown | Regulate Th2 factors [160] |
| miRNA-202-5P | Upregulation | MATN2 | Promote M2 polarization [161] |
| miRNA-202-5p | Upregulation | MATN2 | Promote Tregs polarization [162] |
| miRNA-17-5P | Upregulation | ABCA1/CD69 | Aggravate seasonal AR [163] |
| miRNA-375 | Upregulation | JAK2/STAT3 | Ameliorate AR [164] |
| miRNA-223-3p | Upregulation | INPP4A | Enhance eosinophil infiltration [165] |
| miRNA-let-7a | Upregulation | OPEN | Regulate Th2 cells [166] |
| miRNA-17-92 | Upregulation | Unknown | Exacerbate AR Inflammation [167] |
| miRNA-15a-5p | Downregulation | ADRB2 | Inhibit IL-13 levels [168] |
| miRNA-155 | Downregulation | SOCS1and SIRT1 | Promote Tregs differentiation [169] |
| miRNA-181a | Downregulation | PI3K/AKT | Upregulate IL-10 and TGF-β [169] |
| miRNA-146a | Downregulation | TLR4/TRAF6/NF-κB | Regulate Th2 cells [170] |
| miRNA-466a-3p | Downregulation | GATA3 | Attenuate inflammation [171] |
| miRNA-345-5p | Downregulation | TLR4/NF-κB | Increase anti-inflammatory factors [172] |
| miRNA-29 | Downregulation | CD276 | Reduce IL-4, IL-6 level [173] |
| miRNA-133b | Downregulation | Nlrp3 | Ameliorate allergic inflammation [174] |
| miRNA-106b | Downregulation | Egr-2 | Regulate Th2 polarisation [175] |
| miRNA-143 | Downregulation | IL13Ra1 | Inhibit inflammation [176] |
| miRNA-30a-5p | Downregulation | SOCS3 | Involved in AR pathogenesis [177] |
| miRNA-135a | Downregulation | Unknown | Regulate Th1/Th2 imbalance [11] |
| miRNA-let-7e | Downregulation | SOCS4 | Anti-inflammatory [127, 128] |
| miRNA-16 | Downregulation | IκB kinase β/NF-κB | Inhibit IL-13 secretion [128] |
| miRNA-487b | Downregulation | IL-33/ST2 | Inhibit IL-13 secretion [178] |
| lncRNA SNHG16 | Upregulation | miR-106b-5p/JAK1/STAT3 | Promote inflammation [179] |
| lncRNAGABPA-9 : 1, NR103763, CCL21, APOA2, RAD9B-1 : 4 | Upregulation | Unknown | Involved in AR pathogenesis [134] |
| lncRNA-ANRIL | Upregulation | miR-15a-5p/JAK2 | Suppress inflammation [143] |
| lncRNA-NEAT1 | Upregulation | miR-21, miR-125a | Affect allergy inflammation [180] |
| lncRNA-GAS-5 | Downregulation | EZH2 and T-bet | Promote Th2 differentiation [181] |
| lncRNA-GAS-5 | Downregulation | miR-21 and miR-140 | Affect Th1/Th2 imbalance [182] |
| lncRNAFOXD3-AS1 | Downregulation | Unknown | Inhibit Th2 immunoreaction [183] |
| LncRNATCONS_00147848 | Downregulation | JAK/STAT3 | Reduce inflammatory response [184] |
| lncRNA-000632 | Downregulation | miRNA-498 | Inhibit IL-13[143] |
| circRNA-HIPK3 | Upregulation | miRNA-495 | Promote Th2 differentiation [158] |
| circRNA-ARRDC3 | Downregulation | miR-375/KLF4 | Promote inflammatory [185] |
| circRNA-0000520 | Downregulation | miR-556-5p/NLRP3 | Attenuate inflammatory [186] |
|
