Review Article
Role of Ezrin in Asthma-Related Airway Inflammation and Remodeling
Table 2
Regulation of ezrin by other proteins.
| Proteins | Biological effects | References |
| Intracellular adhesion molecules-1 (ICAM-1) Intracellular adhesion molecules-1 (ICAM-2) | PIP2 binds to cytoplasmic tails of ICAM-1, -2, forming ezrin-multiprotein-complexes | [81] | CD44 | The cytoplasmic tail of CD44 forms a complex with FERM or with the full-length ezrin | [82] | CD43 | Regulates T-cell trafficking through Ser76 within its cytoplasmic tail | [83] | E-cadherin | Activate GTPase Rac1 | [84] | Na+/H+ exchanger 1 (NHE1) | Activate and target ezrin to specific plasma membrane domains, regulate cell survival | [85, 86] | exchanger regulatory factor (NHERF1)/ERM-binding phosphoprotein 50 (EBP50) NHE3 kinase (E3KARP)/NHERF2 | Anchor to the plasma membrane using postsynaptic density proteins | [23, 87] | Protein kinase A (PKA) Cystic fibrosis transmembrane conductance regulator (CFTR) | PKA associates with CFTR via interaction with ezrin | [88] |
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