Hepatoprotective Effect of Mitochondria-Targeted Antioxidant Mito-TEMPO against Lipopolysaccharide-Induced Liver Injury in Mouse

Figure 4

Mito-TEMPO improves mitochondrial function in LPS-induced sepsis. (a) Representative transmission electron microscopy images of mitochondria in the liver of LPS-induced sepsis mice (, 1 μm). (b) Measurement of mtDNA copy numbers in the liver of mice. (c) The liver protein levels of PGC-1α as assessed by western blot. (d) The liver mRNA levels of PGC-1α as assessed by qPCR. (e, f) The proportion of HSP60-positive cells in the liver was determined by immunofluorescence (). per group. Data are presented as the from at least three independent experiments. , , , and .

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