The Role of Cytokines in Nephrotic Syndrome

Figure 1

Cytokines can identify the SRNS cases before therapy. Different levels of 13 plasma cytokines were observed between SSNS versus SRNS before therapy, three of which (MCP-1, IL-9, and L-7) had values to discriminate SRNS from SSNS prior to glucocorticoid therapy with , 0.64 sensitivity, and 0.84 specificity. FGF: fibroblast growth factor; MCP-1: monocyte chemoattractant protein-1; MIP-1β: macrophage inflammatory protein-1β; SSNS: steroid-sensitive nephrotic syndrome; SRNS: steroid-resistant nephrotic syndrome; TNF: tumor necrosis factor; ROC: receiver operating characteristic. Adapted from Ref. [28] with permission. The reference [28] article is available under the Creative Commons CC-BY-NC-ND license.